Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309813 | 0.90 | NLRP3 (0.38) | NLRP3KMT2ATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL24309831 | 0.87 | KAT6A (0.41) | NLRP3SMN1; SMN2ALDH1A1HTTL3MBTL1 | |
| SCHEMBL24310058 | 0.87 | GAA (0.38) | NLRP3SMN1; SMN2ALDH1A1HTTL3MBTL1 | |
| SCHEMBL24309501 | 0.86 | MALT1 (0.37) | NLRP3SMN1; SMN2ALDH1A1HTTL3MBTL1 | |
| SCHEMBL24309731 | 0.85 | HTR1A (0.38) | NLRP3SMN1; SMN2ALDH1A1HTTL3MBTL1 | |
| SCHEMBL24309573 | 0.85 | HTR1A (0.38) | NLRP3SMN1; SMN2ALDH1A1HTTL3MBTL1 | |
| SCHEMBL24309266 | 0.84 | NLRP3 (0.41) | NLRP3KMT2ATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL24309435 | 0.84 | PDE10A (0.38) | PDE10ANLRP3SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL24309413 | 0.84 | KAT6A (0.35) | NLRP3SMN1; SMN2ALDH1A1HTTL3MBTL1 | |
| SCHEMBL24309403 | 0.84 | PTPN1 (0.35) | NLRP3SMN1; SMN2ALDH1A1HTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |