Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 2/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | HEXA | P06865 | 1/20 | 0.31 |
| ▸ | HEXB | P07686 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.30 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | MERTK | Q12866 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310071 | 0.81 | LCK (0.35) | IGF1RJAK3 | |
| SCHEMBL24310802 | 0.76 | IGF1R (0.31) | IGF1R | |
| SCHEMBL24309589 | 0.76 | EGFR (0.34) | JAK2IGF1RJAK3 | |
| SCHEMBL29566902 | 0.76 | HTR1A (0.40) | KDM5AKDM4E | |
| SCHEMBL24309497 | 0.76 | HTR1A (0.40) | KDM5AKDM4E | |
| SCHEMBL24309785 | 0.73 | MAP4K1 (0.33) | IGF1R | |
| SCHEMBL24309682 | 0.70 | CCNT1 (0.32) | TLR8 | |
| SCHEMBL24310066 | 0.70 | HTR1A (0.38) | KDM5AJAK2KDM4E | |
| SCHEMBL26811522 | 0.69 | HTR1A (0.37) | KDM5AKDM4E | |
| SCHEMBL24310383 | 0.68 | KDM5A (0.32) | KDM5AKDM4EIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |