Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.34 |
| ▸ | CTSC | P53634 | 5/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 3/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29566585 | 0.85 | HTR2C (0.42) | METRAF1BRAFJAK2JAK3 | |
| SCHEMBL24309506 | 0.85 | HTR2C (0.42) | METRAF1BRAFJAK2JAK3 | |
| SCHEMBL24310457 | 0.83 | BRD4 (0.39) | PTK2ADRA2CEGFR | |
| SCHEMBL24309467 | 0.83 | EGFR (0.37) | ADRA2CEGFR | |
| SCHEMBL24310296 | 0.82 | SOS1 (0.35) | SOS1 | |
| SCHEMBL24309230 | 0.80 | EGFR (0.32) | JAK2HTR2AHTR7HTR1AEGFR | |
| SCHEMBL24309593 | 0.80 | KDM4E (0.33) | JAK2HTR2AHTR7HTR1AEGFR | |
| SCHEMBL24309736 | 0.79 | CDK2 (0.32) | — | |
| SCHEMBL24310447 | 0.77 | USP1 (0.33) | JAK2JAK3 | |
| SCHEMBL24310509 | 0.77 | CDK2 (0.32) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |