Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 2/20 | 0.33 |
| ▸ | WDR48 | Q8TAF3 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | GPR39 | O43194 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309699 | 0.89 | F2 (0.32) | GPR39 | |
| SCHEMBL24310444 | 0.81 | NAT1 (0.38) | ALDH1A1 | |
| SCHEMBL29566843 | 0.81 | NAT1 (0.38) | ALDH1A1 | |
| SCHEMBL24310804 | 0.81 | LMNA (0.39) | USP1WDR48 | |
| SCHEMBL24309507 | 0.80 | CYP1A2 (0.35) | MAP4K4GPR39 | |
| SCHEMBL24309696 | 0.80 | HSP90AA1 (0.35) | USP1WDR48 | |
| SCHEMBL24309257 | 0.79 | USP1 (0.33) | USP1WDR48 | |
| SCHEMBL24298137 | 0.78 | GPR39 (0.35) | ALDH1A1GPR39 | |
| SCHEMBL24330884 | 0.77 | F10 (0.40) | GPR39 | |
| SCHEMBL24310766 | 0.76 | GPR39 (0.44) | ALDH1A1GAAGPR39 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |