Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309902 | 0.91 | IGF1R (0.37) | LTA4HLCKJAK3BTKTNK2 | |
| SCHEMBL24309862 | 0.87 | TNK2 (0.32) | BTKTNK2IGF1R | |
| SCHEMBL24310025 | 0.86 | TNK2 (0.35) | LTA4HLCKJAK3BTKTNK2 | |
| SCHEMBL24309676 | 0.84 | FLT3 (0.38) | LTA4HHTR7HTR1AIGF1RCYP1A2 | |
| SCHEMBL24310424 | 0.84 | PDE2A (0.41) | JAK3IGF1RCDK6CCNKCCNA2 | |
| SCHEMBL24310428 | 0.84 | MAP4K1 (0.38) | JAK3TNK2IGF1RCDK6CCNK | |
| SCHEMBL24310158 | 0.83 | MAP4K1 (0.37) | JAK3TNK2IGF1RCDK6CCNK | |
| SCHEMBL24309830 | 0.82 | IGF1R (0.32) | IGF1R | |
| SCHEMBL24309719 | 0.82 | MAP4K1 (0.37) | JAK3TNK2IGF1RCDK6CCNK | |
| SCHEMBL24309882 | 0.82 | MAP4K1 (0.37) | JAK3TNK2IGF1RCDK6CCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |