Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 8/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.35 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.35 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309744 | 0.91 | LTA4H (0.38) | IGF1RLTA4HHTR3EHTR3BADRB1 | |
| SCHEMBL24309903 | 0.84 | NOD2 (0.39) | IGF1RLTA4HACVR1RIPK2LCK | |
| SCHEMBL29566801 | 0.84 | NOD2 (0.39) | IGF1RLTA4HACVR1RIPK2LCK | |
| SCHEMBL24309392 | 0.84 | BRD4 (0.37) | IGF1RJAK3TNK2 | |
| SCHEMBL24309676 | 0.83 | FLT3 (0.38) | IGF1RLTA4HACVR1TGFBR1BMPR1A | |
| SCHEMBL24310025 | 0.82 | TNK2 (0.35) | IGF1RLTA4HACVR1LCKJAK3 | |
| SCHEMBL24310428 | 0.82 | MAP4K1 (0.38) | IGF1RJAK3TNK2 | |
| SCHEMBL24310424 | 0.82 | PDE2A (0.41) | IGF1RJAK3 | |
| SCHEMBL24310158 | 0.81 | MAP4K1 (0.37) | IGF1RJAK3TNK2 | |
| SCHEMBL24309719 | 0.80 | MAP4K1 (0.37) | IGF1RJAK3TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |