Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | LTA4H | P09960 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.33 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310587 | 0.91 | FLT3 (0.37) | FLT3LTA4HMAP4K1MAPK10MAPK8 | |
| SCHEMBL24309667 | 0.89 | FLT3 (0.36) | FLT3LTA4HHTR7MAPK10TGFBR1 | |
| SCHEMBL24309516 | 0.88 | FLT3 (0.35) | FLT3LTA4HHTR1AMAPK10MAPK8 | |
| SCHEMBL24309866 | 0.84 | FLT3 (0.36) | FLT3LTA4HHTR7HTR1AMAPK10 | |
| SCHEMBL24309611 | 0.84 | CDK1 (0.34) | FLT3LTA4HHTR1AMAPK10MAPK8 | |
| SCHEMBL24309743 | 0.84 | LTA4H (0.41) | FLT3LTA4HHTR1AMAPK10MAPK8 | |
| SCHEMBL24309744 | 0.84 | LTA4H (0.38) | FLT3LTA4HCYP1A2HTR7HTR1A | |
| SCHEMBL24309902 | 0.83 | IGF1R (0.37) | FLT3LTA4HHTR7HTR1ATGFBR1 | |
| SCHEMBL29566726 | 0.83 | RIPK2 (0.39) | FLT3LTA4HCYP1A2HTR7HTR1A | |
| SCHEMBL26807316 | 0.83 | RIPK2 (0.39) | FLT3LTA4HCYP1A2HTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |