Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.32 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29566628 | 0.82 | PIK3CG (0.40) | PIK3CDPIK3CBPIK3CG | |
| SCHEMBL26808816 | 0.82 | PIK3CG (0.40) | PIK3CDPIK3CBPIK3CG | |
| SCHEMBL24309830 | 0.81 | IGF1R (0.32) | JAK2JAK1 | |
| SCHEMBL24309862 | 0.81 | TNK2 (0.32) | JAK2JAK1 | |
| SCHEMBL24310590 | 0.77 | IGF1R (0.31) | JAK2JAK1 | |
| SCHEMBL24309723 | 0.77 | JAK2 (0.34) | JAK2JAK1 | |
| SCHEMBL24309551 | 0.76 | FYN (0.32) | — | |
| SCHEMBL24309478 | 0.76 | IRAK1 (0.34) | CYP2C9ACVR2ATGFBR2KCNH2IRAK1 | |
| SCHEMBL24310780 | 0.76 | ACVR2A (0.36) | CYP2C9ACVR2ATGFBR2KCNH2IRAK1 | |
| SCHEMBL24310693 | 0.75 | EGFR (0.33) | CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |