Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK1 | P51617 | 3/20 | 0.34 |
| ▸ | ACVR2A | P27037 | 2/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.30 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.30 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310780 | 0.87 | ACVR2A (0.36) | IRAK1ACVR2ATGFBR2CYP2C9KCNH2 | |
| SCHEMBL29566657 | 0.81 | PIK3CG (0.41) | IRAK1ACVR2ATGFBR2CYP2C9KCNH2 | |
| SCHEMBL26806504 | 0.81 | PIK3CG (0.41) | IRAK1ACVR2ATGFBR2CYP2C9KCNH2 | |
| SCHEMBL24309553 | 0.81 | MAP4K1 (0.31) | MAP4K1 | |
| SCHEMBL24310079 | 0.81 | ACVR2A (0.37) | IRAK1ACVR2ATGFBR2CYP2C9KCNH2 | |
| SCHEMBL24309990 | 0.80 | CYP19A1 (0.36) | ACVR2ATGFBR2CYP2C9KCNH2FFAR1 | |
| SCHEMBL24310347 | 0.79 | GPR39 (0.39) | CYP2C9 | |
| SCHEMBL24309575 | 0.79 | NPC1 (0.33) | — | |
| SCHEMBL24310627 | 0.79 | WNT1 (0.33) | IRAK4MAP4K1PIM1 | |
| SCHEMBL24309556 | 0.78 | MAP4K1 (0.35) | MAP4K1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |