Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QDPR | P09417 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 7/20 | 0.41 |
| ▸ | TNKS | O95271 | 4/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL241200 | 0.86 | SLC18A3 (0.50) | QDPRSLC18A3SIGMAR1HTR2CTNKS | |
| SCHEMBL23931791 | 0.86 | CA12 (0.52) | CA12CA1CA9 | |
| Hydrochloric Acid SCHEMBL1765191 | 0.84 | HTR2C (0.48) | QDPRSLC18A3SIGMAR1HTR2CTNKS | |
| SCHEMBL3384000 | 0.78 | SLC18A3 (0.42) | QDPRSLC18A3SIGMAR1HTR2CKCNH2 | |
| SCHEMBL7532624 | 0.78 | CA12 (0.43) | CA12CA1CA9 | |
| SCHEMBL26407761 | 0.78 | HTR2C (0.56) | QDPRSLC18A3SIGMAR1HTR2CTNKS | |
| SCHEMBL24067500 | 0.77 | SLC18A3 (0.64) | QDPRSLC18A3SIGMAR1HTR2CPTPN5 | |
| SCHEMBL13406398 | 0.76 | HCAR1 (0.44) | QDPRSLC18A3SIGMAR1HTR1ASLC6A2 | |
| SCHEMBL24309521 | 0.75 | QDPR (0.51) | QDPRCA12CA1CA9TNKS | |
| SCHEMBL23642132 | 0.75 | HTR2C (0.64) | SLC18A3SIGMAR1HTR2CTNKSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS, SAN DIEGO | 2023-11-23 | — | — | US | disclosed |
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS, SAN DIEGO | 2023-11-23 | — | — | US | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | CFTR, SCNN1G, SCNN1B | QDPR 1331/4885CA12 4521/4885CA1 4872/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.