Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310084 | 0.91 | LMNA (0.36) | LMNAHTT | |
| SCHEMBL24310613 | 0.89 | LMNA (0.43) | LMNAHTTDHODH | |
| SCHEMBL24310804 | 0.88 | LMNA (0.39) | LMNAHTT | |
| SCHEMBL24310227 | 0.87 | HTT (0.36) | LMNAHTT | |
| SCHEMBL24310141 | 0.85 | LMNA (0.35) | LMNAHTTTP53 | |
| SCHEMBL24310181 | 0.85 | LMNA (0.37) | LMNAHTTDHODHTP53SMN1; SMN2 | |
| SCHEMBL24310216 | 0.84 | LMNA (0.38) | LMNAHTTDHODHTP53SMN1; SMN2 | |
| SCHEMBL24310109 | 0.84 | LMNA (0.38) | LMNAHTT | |
| SCHEMBL24310230 | 0.82 | TDP1 (0.42) | LMNAHTTSMN1; SMN2 | |
| SCHEMBL29566388 | 0.82 | TDP1 (0.42) | LMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |