Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.32 |
| ▸ | FEN1 | P39748 | 3/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | GPR39 | O43194 | 1/20 | 0.31 |
| ▸ | USP1 | O94782 | 1/20 | 0.31 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.31 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.31 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.31 |
| ▸ | CTSA | P10619 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310804 | 0.92 | LMNA (0.39) | LMNAHTTBRD4ALOX5APFEN1 | |
| SCHEMBL24310109 | 0.92 | LMNA (0.38) | LMNAHTTBRD4ALOX5APFEN1 | |
| SCHEMBL24310216 | 0.92 | LMNA (0.38) | LMNAHTTBRD4FFAR1DHODH | |
| SCHEMBL24310227 | 0.92 | HTT (0.36) | LMNAHTTBRD4CTSA | |
| SCHEMBL24310181 | 0.91 | LMNA (0.37) | LMNAHTTDHODHBRAFCTSA | |
| SCHEMBL24310084 | 0.91 | LMNA (0.36) | LMNAHTTBRAFADORA2ACTSA | |
| SCHEMBL24310141 | 0.90 | LMNA (0.35) | LMNAHTTBRAFCTSA | |
| SCHEMBL24310231 | 0.89 | LMNA (0.35) | LMNAHTTDHODH | |
| SCHEMBL24309672 | 0.88 | HTT (0.38) | LMNAHTTBRAFALOX5APFEN1 | |
| SCHEMBL24309661 | 0.87 | LMNA (0.37) | LMNAHTTBRD4DHODHALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |