Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GPR39 | O43194 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 5/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310446 | 0.90 | MAPT (0.46) | MAPTCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL24309777 | 0.85 | LMNA (0.38) | MAPTCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL24309787 | 0.83 | MAPT (0.36) | MAPTCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL24309748 | 0.83 | L3MBTL1 (0.38) | MAPTCYP1A2MEN1KMT2AHTT | |
| SCHEMBL24309752 | 0.82 | MAPK1 (0.57) | MAPTCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL24309620 | 0.80 | MAPT (0.41) | MAPTCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL24309989 | 0.79 | MAPT (0.40) | MAPTCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL24309979 | 0.78 | MAPT (0.40) | MAPTCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL24310308 | 0.75 | KDM4E (0.50) | MAPTCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL24309299 | 0.74 | TSHR (0.56) | MAPTCYP1A2CYP2C9CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |