Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 13/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 10/20 | 0.45 |
| ▸ | CPA1 | P15085 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13416058 | 0.90 | EPHX1 (0.56) | EPHX1 | |
| SCHEMBL14959410 | 0.85 | MME (0.48) | MMEEPHX1ACEMMEL1 | |
| SCHEMBL24404148 | 0.84 | MME (0.48) | MMEEPHX1ACEMMEL1 | |
| SCHEMBL24404163 | 0.84 | MME (0.48) | MMEEPHX1ACEMMEL1 | |
| SCHEMBL24154280 | 0.80 | CYP1A2 (0.43) | EPHX1 | |
| SCHEMBL20393649 | 0.80 | SLC6A4 (0.59) | MMEACECPA1ACE2 | |
| SCHEMBL14959409 | 0.79 | MME (0.52) | MMEACE | |
| SCHEMBL15203095 | 0.77 | ACE (0.47) | MMEACECPA1ACE2 | |
| SCHEMBL24153337 | 0.77 | ACE (0.47) | MMEACECPA1ACE2 | |
| SCHEMBL18647222 | 0.76 | MME (0.50) | MMEACECPA1ACE2MMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220106361-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2022-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220106361-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | PAICS, CYCS, LSS | MME 1796/4885EPHX1 1669/4885ACE 176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.