Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 14/20 | 0.52 |
| ▸ | ACE | P12821 | 9/20 | 0.48 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.46 |
| ▸ | PSAT1 | Q9Y617 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14959410 | 0.80 | MME (0.48) | MMEACESRRPSAT1 | |
| SCHEMBL14870613 | 0.80 | MME (0.50) | MMEACE | |
| SCHEMBL24311665 | 0.79 | MME (0.47) | MMEACE | |
| SCHEMBL247680 | 0.79 | EPHX1 (0.53) | MME | |
| SCHEMBL16235149 | 0.75 | CTRB1 (0.56) | MME | |
| SCHEMBL1912666 | 0.75 | MMEL1 (0.54) | MMEACESRRPSAT1 | |
| SCHEMBL1912529 | 0.75 | MMEL1 (0.54) | MMEACESRRPSAT1 | |
| SCHEMBL4619656 | 0.73 | MAPK1 (0.64) | MME | |
| SCHEMBL3956725 | 0.73 | MAPK1 (0.64) | MME | |
| SCHEMBL24312004 | 0.73 | EPHX1 (0.50) | MMESRRPSAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435409-B1 | SUBSTITUTED AMINOPROPIONIC DERIVATIVES AS NEPRILYSIN INHIBITORS | NOVARTIS AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| EP-2594556-A1 | Substituted aminopropionic derivatives as neprilysin inhibitors | Novartis AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| EP-2594557-A1 | Substituted aminopropionic derivatives as neprilysin inhibitors | Novartis AG (CH) | 2013-05-22 | — | — | EP | disclosed |