Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 10/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3735437 | 0.93 | CA1 (0.49) | TDP1CA1CA2CA7KMT2A | |
| SCHEMBL28531113 | 0.90 | CTSK (0.54) | CTSKCTSS | |
| SCHEMBL8288056 | 0.90 | CTSK (0.47) | TDP1CA1CA2CA7KMT2A | |
| SCHEMBL15469705 | 0.90 | CTSK (0.54) | CTSKCTSS | |
| SCHEMBL2296899 | 0.90 | TDP1 (0.49) | TDP1CA1CA2CA7KMT2A | |
| SCHEMBL2296898 | 0.90 | TDP1 (0.49) | TDP1CA1CA2CA7KMT2A | |
| SCHEMBL28323890 | 0.90 | TDP1 (0.49) | TDP1CA1CA2CA7KMT2A | |
| SCHEMBL19337851 | 0.88 | TDP1 (0.47) | TDP1CA1CA2CA7KMT2A | |
| SCHEMBL26799152 | 0.88 | TDP1 (0.47) | TDP1CA1CA2CA7KMT2A | |
| SCHEMBL21660257 | 0.86 | CTSK (0.49) | TDP1CA1CA2CA7CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220106324-A1 | DISPIROPYRROLIDINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2022-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220106324-A1 | DISPIROPYRROLIDINE DERIVATIVES | MDM2, TP53, TP53BP1 | TDP1 1524/4885CA1 2818/4885CA2 2729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.