Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.46 |
| ▸ | PSAT1 | Q9Y617 | 2/20 | 0.46 |
| ▸ | ANPEP | P15144 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | ACP3 | P15309 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 6/20 | 0.41 |
| ▸ | PPARA | Q07869 | 5/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.40 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | AGXT | P21549 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9908069 | 0.89 | EPHX1 (0.64) | EPHX1ANPEPTAAR1PTGS1 | |
| SCHEMBL11947633 | 0.89 | EPHX1 (0.64) | EPHX1ANPEPTAAR1PTGS1 | |
| SCHEMBL4975192 | 0.89 | EPHX1 (0.64) | EPHX1ANPEPTAAR1PTGS1 | |
| SCHEMBL14959390 | 0.83 | TAAR1 (0.55) | TAAR1FFAR1MMEAGXT | |
| SCHEMBL10273446 | 0.79 | SLC6A4 (0.42) | EPHX1ANPEPTSHR | |
| SCHEMBL18647219 | 0.79 | SRR (0.50) | EPHX1SRRPSAT1TAAR1ACP3 | |
| SCHEMBL24311844 | 0.79 | SRR (0.50) | EPHX1SRRPSAT1TAAR1ACP3 | |
| SCHEMBL13962960 | 0.79 | SRR (0.50) | EPHX1SRRPSAT1TAAR1ACP3 | |
| SCHEMBL10051066 | 0.78 | SLC6A4 (0.67) | EPHX1ANPEPTAAR1PPARGPPARA | |
| SCHEMBL19003879 | 0.78 | SLC6A4 (0.67) | EPHX1ANPEPTAAR1PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220106361-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2022-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220106361-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | PAICS, CYCS, LSS | EPHX1 1669/4885SRR 3486/4885PSAT1 808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.