Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.64 |
| ▸ | DAO | P14920 | 1/20 | 0.59 |
| ▸ | PARP1 | P09874 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 2/20 | 0.40 |
| ▸ | PDE6D | O43924 | 2/20 | 0.40 |
| ▸ | PDE8A | O60658 | 2/20 | 0.40 |
| ▸ | PDE5A | O76074 | 2/20 | 0.40 |
| ▸ | PDE9A | O76083 | 2/20 | 0.40 |
| ▸ | PDE8B | O95263 | 2/20 | 0.40 |
| ▸ | PDE6A | P16499 | 2/20 | 0.40 |
| ▸ | PDE6G | P18545 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE6B | P35913 | 2/20 | 0.40 |
| ▸ | PDE6C | P51160 | 2/20 | 0.40 |
| ▸ | PDE1A | P54750 | 2/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31143069 | 0.78 | DAO (0.65) | ATAD2DAOPARP1KDM4EHRH4 | |
| SCHEMBL24970980 | 0.78 | DAO (0.65) | ATAD2DAOPARP1KDM4EHRH4 | |
| SCHEMBL30663285 | 0.78 | ATAD2 (1.00) | ATAD2DAOPARP1KDM4EHRH4 | |
| SCHEMBL24390514 | 0.75 | ATAD2 (0.66) | ATAD2DAOPARP1KDM4EHRH4 | |
| SCHEMBL3364094 | 0.75 | DAO (1.00) | ATAD2DAOPARP1HRH4PDE2A | |
| SCHEMBL21551043 | 0.74 | ATAD2 (0.64) | ATAD2DAOPARP1KDM4EHRH4 | |
| SCHEMBL22016868 | 0.74 | ATAD2 (0.64) | ATAD2DAOPARP1KDM4EHRH4 | |
| SCHEMBL17601429 | 0.73 | DAO (0.62) | ATAD2DAOPARP1KDM4EHRH4 | |
| SCHEMBL24312485 | 0.73 | BRD4 (0.59) | DAOKDM4EMAPTFGFR1HSD17B10 | |
| SCHEMBL17601265 | 0.72 | ATAD2 (0.60) | ATAD2DAOPARP1KDM4EHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220119383-A1 | QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS | GILEAD SCIENCES, INC. | 2022-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220119383-A1 | QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS | ITGB7, ITGB1, ITGA2B | ATAD2 1807/4885DAO 4523/4885PARP1 1472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.