Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 5/20 | 0.55 |
| ▸ | NOS2 | P35228 | 4/20 | 0.55 |
| ▸ | NOS3 | P29474 | 3/20 | 0.55 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.49 |
| ▸ | GSR | P00390 | 1/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.42 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | ARG2 | P78540 | 4/20 | 0.42 |
| ▸ | ARG1 | P05089 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541602 | 0.87 | NOS1 (0.51) | NOS1NOS2NOS3DDAH1GSR | |
| SCHEMBL18883517 | 0.87 | NOS1 (0.58) | NOS1NOS2NOS3DDAH1GSR | |
| SCHEMBL17841237 | 0.81 | NOS2 (0.64) | NOS1NOS2NOS3GSRARG2 | |
| SCHEMBL16921496 | 0.80 | NOS1 (0.46) | NOS1NOS2NOS3DDAH1GSR | |
| SCHEMBL12492046 | 0.80 | NOS2 (0.67) | NOS1NOS2NOS3DDAH1GSR | |
| SCHEMBL27932086 | 0.80 | NOS2 (0.62) | NOS1NOS2NOS3GSRARG2 | |
| SCHEMBL1768758 | 0.79 | NOS2 (0.53) | NOS1NOS2NOS3DDAH1GSR | |
| SCHEMBL1768756 | 0.79 | NOS2 (0.53) | NOS1NOS2NOS3DDAH1GSR | |
| SCHEMBL27628164 | 0.78 | NOS1 (0.51) | NOS1NOS2NOS3DDAH1GSR | |
| SCHEMBL31370175 | 0.78 | BCHE (0.50) | NOS1NOS2NOS3GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076905-A1 | ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. (US) | 2022-04-14 | — | — | WO | disclosed |