Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 6/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 3/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
| ▸ | TAF1 | P21675 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22016206 | 0.72 | BRPF1 (0.34) | GRM2BRPF1KDM5BLMNAADORA3 | |
| SCHEMBL18651544 | 0.71 | LMNA (0.41) | BRPF1BRD9KDM5BLMNAADORA3 | |
| SCHEMBL25718784 | 0.71 | LMNA (0.37) | BRPF1BRD9KDM5BLMNAADORA3 | |
| SCHEMBL24376287 | 0.69 | KDM4E (0.38) | BRPF1BRD9LMNAADORA3ALDH1A1 | |
| SCHEMBL22017365 | 0.67 | LMNA (0.53) | BRPF1BRD9LMNAADORA3ALDH1A1 | |
| SCHEMBL26815264 | 0.67 | LMNA (0.34) | BRPF1BRD9KDM5BLMNAADORA3 | |
| SCHEMBL26141107 | 0.64 | MAPK1 (0.39) | GRM2LIPGLMNAALDH1A1EGFR | |
| SCHEMBL19078681 | 0.62 | PTPN1 (0.40) | ALDH1A1EGFRRAF1MAPTALOX12 | |
| SCHEMBL31244835 | 0.62 | POLB (0.55) | ALDH1A1 | |
| SCHEMBL2608433 | 0.60 | NPC1 (0.50) | LMNAALDH1A1MAPTL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220119383-A1 | QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS | GILEAD SCIENCES, INC. | 2022-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220119383-A1 | QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS | ITGB7, ITGB1, ITGA2B | GRM2 3291/4885LIPG 2456/4885BRPF1 2879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.