Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21091662 | 0.81 | RAF1 (0.65) | BRAFRAF1 | |
| SCHEMBL16121752 | 0.80 | RAF1 (1.00) | BRAFRAF1 | |
| SCHEMBL17523467 | 0.80 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL16094184 | 0.78 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL16078172 | 0.78 | RAF1 (1.00) | BRAFRAF1 | |
| SCHEMBL22360883 | 0.78 | RAF1 (0.92) | BRAFRAF1 | |
| SCHEMBL16036773 | 0.77 | RAF1 (1.00) | BRAFRAF1 | |
| SCHEMBL29610684 | 0.77 | RAF1 (0.84) | BRAFRAF1 | |
| SCHEMBL24312169 | 0.77 | RAF1 (0.84) | BRAFRAF1 | |
| SCHEMBL20008544 | 0.77 | BRAF (0.56) | BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11377431-B2 | Inhibitors of RAF kinases | KINNATE BIOPHARMA INC. (US) | 2022-07-05 | — | — | US | disclosed |
| US-20220112170-A1 | INHIBITORS OF RAF KINASES | Pierre Fabre Médicament (FR) | 2022-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220112170-A1 | INHIBITORS OF RAF KINASES | BRAF, RAF1, ARAF | BRAF 1/4885RAF1 2/4885 |
| US-11377431-B2 | Inhibitors of RAF kinases | BRAF, RAF1, ARAF | BRAF 1/4885RAF1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.