Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 17/20 | 0.60 |
| ▸ | THRB | P10828 | 9/20 | 0.60 |
| ▸ | MAP3K20 | Q9NYL2 | 4/20 | 0.41 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24312339 | 0.89 | TGFBR1 (0.66) | TGFBR1THRBMAP3K20TGFBR2MAPK14 | |
| SCHEMBL23217993 | 0.87 | TGFBR1 (0.50) | TGFBR1THRBMAP3K20TGFBR2MAPK14 | |
| SCHEMBL24312341 | 0.85 | THRB (0.57) | TGFBR1THRBMAP3K20TGFBR2MAPK14 | |
| SCHEMBL24311916 | 0.77 | TGFBR1 (0.45) | TGFBR1 | |
| SCHEMBL23217940 | 0.77 | TGFBR1 (0.48) | TGFBR1THRBMAP3K20TGFBR2MAPK14 | |
| SCHEMBL412382 | 0.76 | TGFBR1 (1.00) | TGFBR1THRBMAP3K20TGFBR2MAPK14 | |
| SCHEMBL23217922 | 0.75 | TGFBR1 (0.60) | TGFBR1THRBMAP3K20TGFBR2MAPK14 | |
| SCHEMBL24312017 | 0.75 | TGFBR1 (0.60) | TGFBR1THRBMAP3K20TGFBR2MAPK14 | |
| SCHEMBL24312016 | 0.74 | TGFBR1 (0.58) | TGFBR1THRBMAP3K20TGFBR2MAPK14 | |
| SCHEMBL24312440 | 0.72 | TGFBR1 (0.56) | TGFBR1THRBMAP3K20TGFBR2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076905-A1 | ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. (US) | 2022-04-14 | — | — | WO | disclosed |