Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | RAD52 | P43351 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | GALR3 | O60755 | 2/20 | 0.61 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | UBE2N | P61088 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.61 |
| ▸ | EGFR | P00533 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | APP | P05067 | 5/20 | 0.59 |
| ▸ | PDE5A | O76074 | 4/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3758745 | 0.84 | EGFR (0.67) | CYP1A2CYP2D6CYP2C19LMNANR2F2 | |
| SCHEMBL24312409 | 0.81 | CYP1A2 (1.00) | CYP1A2CYP2D6CYP2C19KMT2ALMNA | |
| SCHEMBL4074924 | 0.77 | APP (0.67) | CYP1A2KMT2ARAB9AAPPMEN1 | |
| SCHEMBL12175837 | 0.77 | RAD52 (1.00) | RAD52KMT2ALMNAKDM4EALDH1A1 | |
| SCHEMBL7612718 | 0.76 | EGFR (1.00) | RAD52KMT2ALMNAGALR3NR2F2 | |
| SCHEMBL29386010 | 0.76 | EGFR (1.00) | RAD52KMT2ALMNAGALR3NR2F2 | |
| Hydrochloric Acid SCHEMBL8178476 | 0.75 | LMNA (1.00) | RAD52KMT2ALMNAGALR3NR2F2 | |
| SCHEMBL3977315 | 0.75 | RAD52 (0.71) | RAD52KMT2ALMNAGALR3NR2F2 | |
| SCHEMBL4754065 | 0.75 | APP (0.62) | RAD52KMT2ALMNAGALR3NR2F2 | |
| SCHEMBL3113122 | 0.75 | APP (1.00) | RAD52KMT2ALMNAGALR3NR2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11732286-B2 | T5 exonuclease-based method to identify DNA topoisomerase inhibitors | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2023-08-22 | — | — | US | disclosed |
| US-11732286-B2 | T5 exonuclease-based method to identify DNA topoisomerase inhibitors | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2023-08-22 | — | — | US | disclosed |
| US-20220170070-A1 | T5 EXONUCLEASE-BASED METHOD TO IDENTIFY DNA TOPOISOMERASE INHIBITORS | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2022-06-02 | — | — | US | disclosed |
| US-20220119858-A1 | T5 EXONUCLEASE-BASED METHOD TO IDENTIFY DNA TOPOISOMERASE INHIBITORS | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2022-04-21 | — | — | US | disclosed |
| US-11268129-B1 | T5 exonuclease-based method to identify DNA topoisomerase inhibitors | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2022-03-08 | — | — | US | disclosed |