Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.45 |
| ▸ | KDM5A | P29375 | 8/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | TOP1 | P11387 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11867978 | 0.84 | PARP1 (0.47) | ADORA3ADORA2AADORA1KDM5AFEN1 | |
| SCHEMBL22016197 | 0.83 | ADORA3 (0.42) | ADORA3ADORA2AADORA1KDM5AFEN1 | |
| SCHEMBL4547810 | 0.77 | KDM5A (0.42) | ADORA3ADORA2AADORA1KDM5AFEN1 | |
| SCHEMBL12505228 | 0.75 | ADORA3 (0.59) | ADORA3ADORA2AADORA1KDM5AFEN1 | |
| SCHEMBL22016540 | 0.73 | ADORA3 (0.50) | ADORA3ADORA2AADORA1KDM5AFEN1 | |
| SCHEMBL28763780 | 0.72 | FEN1 (0.76) | ADORA3ADORA2AADORA1KDM5AFEN1 | |
| SCHEMBL22017505 | 0.72 | ADORA3 (0.50) | ADORA3ADORA2AADORA1KDM5AFEN1 | |
| SCHEMBL11870266 | 0.72 | FEN1 (0.60) | ADORA3ADORA2AADORA1FEN1PARP1 | |
| SCHEMBL13361513 | 0.69 | KDM5A (0.51) | ADORA3ADORA2AADORA1KDM5AKDM5B | |
| SCHEMBL8229881 | 0.68 | POLB (0.60) | FEN1PARP1MAOBDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220119383-A1 | QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS | GILEAD SCIENCES, INC. | 2022-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220119383-A1 | QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS | ITGB7, ITGB1, ITGA2B | ADORA3 1388/4885ADORA2A 2215/4885ADORA1 1200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.