Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | KDM5A | P29375 | 5/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | PDE9A | O76083 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CMA1 | P23946 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24312482 | 0.83 | ADORA3 (0.45) | ADORA3ADORA2AADORA1KDM5AFEN1 | |
| SCHEMBL11867978 | 0.76 | PARP1 (0.47) | ADORA3ADORA2AADORA1KDM5AFEN1 | |
| SCHEMBL22016215 | 0.76 | CMA1 (0.38) | ADORA3ADORA2AADORA1KDM5ASMN1; SMN2 | |
| SCHEMBL24437016 | 0.71 | CMA1 (0.38) | ADORA3ADORA2AADORA1KDM5ACMA1 | |
| SCHEMBL24747270 | 0.68 | POLB (0.56) | DAOKDM4EALDH1A1GAAHPGD | |
| SCHEMBL22016540 | 0.67 | ADORA3 (0.50) | ADORA3ADORA2AADORA1KDM5AFEN1 | |
| SCHEMBL23921792 | 0.66 | GPR84 (0.39) | GPR84 | |
| SCHEMBL22017505 | 0.66 | ADORA3 (0.50) | ADORA3ADORA2AADORA1KDM5AFEN1 | |
| SCHEMBL24999045 | 0.66 | GPR84 (0.39) | GPR84 | |
| SCHEMBL8616729 | 0.64 | CYP1A2 (0.37) | ADORA3ADORA2AADORA1FEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-02-09 | — | — | US | disclosed |
| US-11116760-B2 | Quinoline derivatives | GILEAD SCIENCES, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | ADORA3 1752/4885ADORA2A 1362/4885ADORA1 1182/4885 |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | ADORA3 1752/4885ADORA2A 1362/4885ADORA1 1182/4885 |
| US-11116760-B2 | Quinoline derivatives | CFTR, NQO1, IRF3 | ADORA3 1752/4885ADORA2A 1362/4885ADORA1 1182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.