Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30437347 | 1.00 | NPC1 (0.32) | NPC1RAB9AMEN1MAPTKMT2A | |
| SCHEMBL30408785 | 0.82 | NPC1 (0.33) | NPC1RAB9AMEN1MAPTKMT2A | |
| SCHEMBL24251878 | 0.82 | NPC1 (0.33) | NPC1RAB9AMEN1MAPTKMT2A | |
| SCHEMBL24313013 | 0.82 | — | — | |
| SCHEMBL15337285 | 0.75 | NPC1 (0.44) | NPC1RAB9AMEN1MAPTKMT2A | |
| SCHEMBL24313002 | 0.74 | ELANE (0.35) | NPC1RAB9AMEN1MAPTKMT2A | |
| SCHEMBL30082424 | 0.74 | NPC1 (0.38) | NPC1RAB9AMAPTELANE | |
| SCHEMBL24251860 | 0.74 | NPC1 (0.38) | NPC1RAB9AMAPTELANE | |
| SCHEMBL26411604 | 0.73 | METTL3 (0.31) | — | |
| SCHEMBL26411786 | 0.73 | SRC (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116096720-A | Dihydropyrrolo [2,3-d ] pyridazin-7-one derivatives, preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2023-05-09 | — | — | CN | disclosed |
| CN-115867547-A | 1H-pyrazole-4-amide derivative, and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2023-03-28 | — | — | CN | disclosed |
| WO-2022042612-A1 | DIHYDROPYRROLO[2,3-D]PYRIDAZIN-7-ONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 上海和誉生物医药科技有限公司 | 2022-03-03 | — | — | WO | disclosed |