Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 9/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GPR6 | P46095 | 2/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | FABP4 | P15090 | 2/20 | 0.31 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29587622 | 1.00 | SCN9A (0.35) | SCN9AALDH1A1LMNATRPV1KAT6A | |
| SCHEMBL24313960 | 0.97 | TRPV1 (0.35) | SCN9AALDH1A1LMNATRPV1FABP4 | |
| SCHEMBL29587885 | 0.97 | TRPV1 (0.35) | SCN9AALDH1A1LMNATRPV1FABP4 | |
| SCHEMBL29587808 | 0.91 | ALDH1A1 (0.43) | ALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL24314184 | 0.91 | ALDH1A1 (0.43) | ALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL24313805 | 0.89 | ALDH1A1 (0.34) | SCN9AALDH1A1LMNA | |
| SCHEMBL29588213 | 0.89 | ALDH1A1 (0.34) | SCN9AALDH1A1LMNA | |
| SCHEMBL24314323 | 0.88 | SCN9A (0.38) | SCN9A | |
| SCHEMBL29587334 | 0.88 | KCNH2 (0.39) | SCN9AALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL29588250 | 0.88 | SCN9A (0.38) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |