SCHEMBL29587334

SCHEMBL29587334

CC(C)(C)c1ccc(OCC(F)(F)F)c(S(=O)(=O)NC(=O)c2cc3c(F)cc(C4CC4)cc3o2)c1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.39
MCHR1 Q99705 1/20 0.39
CNR2 P34972 11/20 0.35
ALDH1A1 P00352 4/20 0.34
HTT P42858 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
SCN1A P35498 1/20 0.33
SCN4A P35499 1/20 0.33
SCN7A Q01118 1/20 0.33
SCN5A Q14524 1/20 0.33
SCN9A Q15858 1/20 0.33
SCN2A Q99250 1/20 0.33
SCN3A Q9NY46 1/20 0.33
SCN8A Q9UQD0 1/20 0.33
POLB P06746 2/20 0.33
LMNA P02545 1/20 0.33
CTSD P07339 1/20 0.32
CYP3A4 P08684 1/20 0.32
BACE1 P56817 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29588250 0.90 SCN9A (0.38) SCN1ASCN4ASCN7ASCN5ASCN9A
SCHEMBL24314323 0.90 SCN9A (0.38) SCN1ASCN4ASCN7ASCN5ASCN9A
SCHEMBL24313979 0.89 CYP1A2 (0.37) KCNH2MCHR1ALDH1A1HTTSMN1; SMN2
SCHEMBL29587808 0.89 ALDH1A1 (0.43) KCNH2MCHR1ALDH1A1HTTSMN1; SMN2
SCHEMBL24314184 0.89 ALDH1A1 (0.43) KCNH2MCHR1ALDH1A1HTTSMN1; SMN2
SCHEMBL24313683 0.89 KCNH2 (0.40) KCNH2MCHR1CNR2ALDH1A1SMN1; SMN2
SCHEMBL29588383 0.89 LMNA (0.38) CNR2LMNA
SCHEMBL24313813 0.89 LMNA (0.38) CNR2LMNA
SCHEMBL24313699 0.88 SCN9A (0.35) ALDH1A1HTTSMN1; SMN2SCN9ALMNA
SCHEMBL29587622 0.88 SCN9A (0.35) ALDH1A1HTTSMN1; SMN2SCN9ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4229045-B1 SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER BROAD INST INC (US) 2025-11-12 EP claimed
EP-4229045-A1 SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER The Broad Institute Inc. (US) 2023-08-23 EP claimed
WO-2022081842-A1 SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER THE BROAD INSTITUTE, INC. (US) 2022-04-21 WO claimed
EP-4229045-A1 SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER The Broad Institute Inc. (US) 2023-08-23 EP disclosed
WO-2022081842-A1 SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER THE BROAD INSTITUTE, INC. (US) 2022-04-21 WO disclosed