Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 4/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.35 |
| ▸ | CSNK2A3 | Q8NEV1 | 3/20 | 0.35 |
| ▸ | PDE4A | P27815 | 5/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31723096 | 0.90 | PDE4D (0.34) | PDE4APDE4BPDE4CPDE4DTBK1 | |
| SCHEMBL24313906 | 0.80 | PTGER4 (0.45) | PDE4APDE4BPDE4CPDE4DHPGD | |
| SCHEMBL24313907 | 0.79 | PDE2A (0.34) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL24314181 | 0.78 | MCL1 (0.41) | MCL1PIM1CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL29588225 | 0.76 | PTGER4 (0.38) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL24313769 | 0.76 | PTGER4 (0.38) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL24313771 | 0.75 | PDE2A (0.32) | PDE4APDE4BPDE4CPDE4DPDE2A | |
| SCHEMBL24313926 | 0.75 | MCL1 (0.42) | MCL1PIM1CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL29587761 | 0.75 | MCL1 (0.42) | MCL1PIM1CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL24313929 | 0.72 | MCL1 (0.38) | MCL1PIM1CSNK2A1CSNK2A2CSNK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229045-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |