Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 4/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 6/20 | 0.40 |
| ▸ | PGR | P06401 | 3/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24313926 | 1.00 | MCL1 (0.42) | MCL1PIM1PIM2ARPGR | |
| SCHEMBL31723121 | 0.89 | MCL1 (0.42) | MCL1ARPGRKDM4EHPGD | |
| SCHEMBL24314181 | 0.81 | MCL1 (0.41) | MCL1PIM1PIM2CSNK2A1CSNK2A2 | |
| SCHEMBL24313796 | 0.79 | RBP4 (0.42) | KDM4EHPGDMEN1ALDH1A1KMT2A | |
| SCHEMBL24313801 | 0.78 | RAB9A (0.36) | MCL1ARKDM4EHPGDHSD17B10 | |
| SCHEMBL24313929 | 0.75 | MCL1 (0.38) | MCL1PIM1CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL24313729 | 0.75 | MCL1 (0.36) | MCL1PIM1CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL24314320 | 0.74 | SCN9A (0.38) | — | |
| SCHEMBL29587417 | 0.74 | SCN9A (0.38) | — | |
| SCHEMBL24314321 | 0.73 | MAPK1 (0.35) | KDM4EHPGDMEN1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229045-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |