Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 5/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.41 |
| ▸ | CSNK2A3 | Q8NEV1 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31723087 | 0.88 | PPP5C (0.33) | TBK1IKBKE | |
| SCHEMBL31723088 | 0.88 | PPP5C (0.33) | TBK1IKBKE | |
| SCHEMBL29587761 | 0.81 | MCL1 (0.42) | MCL1PIM1CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL24313926 | 0.81 | MCL1 (0.42) | MCL1PIM1CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL24313929 | 0.78 | MCL1 (0.38) | MCL1PIM1CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL24313729 | 0.78 | MCL1 (0.36) | MCL1PIM1CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL24313633 | 0.77 | HPGD (0.44) | KDM4EHPGDL3MBTL1PTGS1 | |
| SCHEMBL24313634 | 0.76 | RAB9A (0.34) | KDM4EMAPTHPGDHTTHSD17B10 | |
| SCHEMBL22588089 | 0.74 | MCL1 (0.53) | MCL1PIM1CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL31723099 | 0.72 | PTGER4 (0.36) | KDM4EHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |