Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
| ▸ | KLK1 | P06870 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29469950 | 1.00 | FFAR1 (0.52) | FFAR1SLC2A1MAPTMAPK1TDP1 | |
| SCHEMBL682767 | 0.85 | MAPT (0.49) | MAPTMAPK1TDP1L3MBTL1CCR5 | |
| SCHEMBL12889910 | 0.83 | GLRA1 (0.50) | MAPTMAPK1TDP1L3MBTL1CCR5 | |
| SCHEMBL12868786 | 0.83 | FFAR4 (0.54) | FFAR1MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL12738664 | 0.81 | NPC1 (0.55) | MAPTALDH1A1RAB9AF2APP | |
| SCHEMBL14200026 | 0.81 | MAPT (0.45) | MAPTMAPK1TDP1L3MBTL1CCR5 | |
| SCHEMBL10172543 | 0.81 | NPC1 (0.52) | MAPTMAPK1TDP1L3MBTL1CCR5 | |
| SCHEMBL17833745 | 0.81 | SMPD1 (0.53) | MAPK1ALDH1A1RAB9AF2APP | |
| SCHEMBL10148264 | 0.81 | MRGPRX4 (0.56) | FFAR1MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL14200042 | 0.79 | KEAP1 (0.53) | MAPTMAPK1TDP1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |