Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | PDE4A | P27815 | 5/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22588464 | 0.86 | P2RX4 (0.43) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29469834 | 0.79 | CA1 (0.41) | ALDH1A1PDE4BSMN1; SMN2 | |
| SCHEMBL13678369 | 0.78 | CSNK2A1 (0.51) | PDE4ANPSR1HTR2CHTR2BHPGD | |
| SCHEMBL31372170 | 0.78 | CSNK2A1 (0.43) | PDE4APDE4BPDE4CPDE4DPOLB | |
| SCHEMBL10641518 | 0.77 | ALDH1A1 (0.57) | ALDH1A1TRPV4SMN1; SMN2POLBNPSR1 | |
| SCHEMBL29469921 | 0.77 | ALDH1A1 (0.44) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL24313728 | 0.77 | ALDH1A1 (0.44) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13450374 | 0.76 | PDE4A (0.40) | ALDH1A1PDE4APDE4BSMN1; SMN2NPSR1 | |
| SCHEMBL13499052 | 0.75 | CSNK2A1 (0.55) | PDE4ANPSR1HTR2CHTR2BHPGD | |
| SCHEMBL24313936 | 0.75 | HTR2C (0.40) | PDE4APDE4BPDE4CPDE4DNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |