Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24313728 | 1.00 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2PDE4BTSHRKMT2A | |
| SCHEMBL29587949 | 0.86 | RORC (0.46) | ALDH1A1SMN1; SMN2PDE4BTSHRKMT2A | |
| SCHEMBL22588071 | 0.86 | RORC (0.46) | ALDH1A1SMN1; SMN2PDE4BTSHRKMT2A | |
| SCHEMBL24314213 | 0.82 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2TSHRKMT2AALPL | |
| SCHEMBL741127 | 0.81 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2TSHRKMT2AALPL | |
| SCHEMBL13678313 | 0.79 | KMO (0.47) | PDE4BPDE4APDE4CPDE4DHPGD | |
| SCHEMBL31371876 | 0.78 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2TSHRKMT2AALPL | |
| SCHEMBL16852267 | 0.77 | PDE4B (0.43) | ALDH1A1SMN1; SMN2PDE4BPDE4APDE4C | |
| SCHEMBL24314301 | 0.77 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2TSHRKMT2AALPL | |
| SCHEMBL24314285 | 0.77 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2PDE4BTSHRPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| EP-4229045-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |