Sugi Predict

Sugi Predict / Compounds / SCHEMBL24315554

SCHEMBL24315554

SCHEMBL24315554

O=C1[C@H](Cc2ccc(O)cc2)N2C(=O)C[C@@H](CO)N(C(=O)NCc3ccccc3)[C@H]2CN1Cc1cccc2ncccc12

nearest known ligand 0.60

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ CLPP Q16740 3/20 0.60
▸ CTNNB1 P35222 2/20 0.60
▸ TCF7 P36402 2/20 0.60
▸ BCL9 O00512 1/20 0.60
▸ TCF4 P15884 1/20 0.60
▸ CREBBP Q92793 1/20 0.60
▸ CYP3A4 P08684 16/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26667491 0.91 CLPP (0.73) CLPPCTNNB1TCF7BCL9TCF4
SCHEMBL26667485 0.91 CLPP (0.73) CLPPCTNNB1TCF7BCL9TCF4
SCHEMBL29515313 0.91 CLPP (0.73) CLPPCTNNB1TCF7BCL9TCF4
SCHEMBL24315624 0.91 CLPP (0.73) CLPPCTNNB1TCF7BCL9TCF4
SCHEMBL26667484 0.91 CLPP (0.73) CLPPCTNNB1TCF7BCL9TCF4
SCHEMBL29492584 0.91 CLPP (0.73) CLPPCTNNB1TCF7BCL9TCF4
SCHEMBL24315589 0.91 CLPP (0.73) CLPPCTNNB1TCF7BCL9TCF4
SCHEMBL25434104 0.91 CLPP (0.73) CLPPCTNNB1TCF7BCL9TCF4
SCHEMBL26451028 0.90 CLPP (0.59) CLPPCTNNB1TCF7BCL9TCF4
SCHEMBL24315558 0.86 CTNNB1 (0.52) CLPPCTNNB1TCF7BCL9TCF4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230374020-A1 SUBSTITUTED IMIDAZO[l,2-a]PYRAZINES AND PYRAZINO[l,2-a] PYRIMIDINES AS TOPICAL AGENTS FOR DERMATOLOGICAL APPLICATIONS Genesis Molecular Technologies, Inc. 2023-11-23 — — US disclosed
US-20230374020-A1 SUBSTITUTED IMIDAZO[l,2-a]PYRAZINES AND PYRAZINO[l,2-a] PYRIMIDINES AS TOPICAL AGENTS FOR DERMATOLOGICAL APPLICATIONS Genesis Molecular Technologies, Inc. 2023-11-23 — — US disclosed
US-11639356-B2 Substituted imidazo[1,2-a]pyrazines and pyrazino[1,2-a]pyrimidines as topical agents for dermatological applications Genesis Molecular Technologies, Inc. (US) 2023-05-02 — — US disclosed
US-11639356-B2 Substituted imidazo[1,2-a]pyrazines and pyrazino[1,2-a]pyrimidines as topical agents for dermatological applications Genesis Molecular Technologies, Inc. (US) 2023-05-02 — — US disclosed
US-20220106320-A1 TOPICAL AGENTS FOR DERMATOLOGICAL APPLICATIONS Genesis Molecular Technologies, Inc. 2022-04-07 — — US disclosed
US-9585884-B2 Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 AUSPEX PHARMACEUTICALS, INC. (US) 2017-03-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11639356-B2 Substituted imidazo[1,2-a]pyrazines and pyrazino[1,2-a]pyrimidines as topical agents for dermatological applications CREBBP, CREB1, PRKACA CLPP 3050/4885CTNNB1 4/4885TCF7 55/4885
US-20220106320-A1 TOPICAL AGENTS FOR DERMATOLOGICAL APPLICATIONS CREBBP, EBP, CREB1 CLPP 2598/4885CTNNB1 6/4885TCF7 74/4885
US-20230374020-A1 SUBSTITUTED IMIDAZO[l,2-a]PYRAZINES AND PYRAZINO[l,2-a] PYRIMIDINES AS TOPICAL AGENTS FOR DERMATOLOGICAL APPLICATIONS CREBBP, CREB1, EP300 CLPP 2590/4885CTNNB1 4/4885TCF7 74/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.