Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 15/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PDE9A | O76083 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22623767 | 0.88 | CRBN (0.44) | CRBNDDB1POLB | |
| SCHEMBL25046231 | 0.88 | CRBN (0.44) | CRBNDDB1POLB | |
| SCHEMBL10073932 | 0.88 | CRBN (0.44) | CRBNDDB1POLB | |
| SCHEMBL2956440 | 0.74 | MAP3K14 (0.44) | CRBNDDB1POLB | |
| SCHEMBL20329585 | 0.72 | CRBN (0.46) | CRBNDDB1 | |
| SCHEMBL25467406 | 0.72 | TLR4 (0.32) | POLB | |
| SCHEMBL765417 | 0.72 | — | — | |
| SCHEMBL2690883 | 0.72 | — | — | |
| SCHEMBL17427855 | 0.72 | — | — | |
| SCHEMBL10160076 | 0.71 | L3MBTL1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081925-A1 | TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| US-9585884-B2 | Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2017-03-07 | — | — | US | disclosed |