Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | LTK | P29376 | 1/20 | 0.33 |
| ▸ | GRK5 | P34947 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20204612 | 0.75 | CA1 (0.38) | DAOHPGDCHEK1AURKAMAP4K4 | |
| SCHEMBL14793837 | 0.72 | HMBS (0.43) | DAOCHEK1AURKAMAP4K4ABL1 | |
| SCHEMBL12180269 | 0.72 | DAO (0.39) | DAOALDH1A1HPGDCHEK1AURKA | |
| SCHEMBL26620926 | 0.72 | DAO (0.39) | DAOALDH1A1HPGDKDM4E | |
| SCHEMBL19372888 | 0.71 | CHEK1 (0.39) | DAOALDH1A1CHEK1AURKAMAP4K4 | |
| SCHEMBL24315871 | 0.71 | EIF4A3 (0.37) | DAOCHEK1AURKAMAP4K4ABL1 | |
| SCHEMBL4265547 | 0.69 | ALDH1A1 (0.39) | DAOALDH1A1 | |
| SCHEMBL24315863 | 0.68 | HCAR2 (0.34) | DAOCHEK1AURKAMAP4K4ABL1 | |
| SCHEMBL24315859 | 0.68 | CHEK1 (0.33) | DAOALDH1A1CHEK1AURKAMAP4K4 | |
| SCHEMBL22185346 | 0.68 | PARP1 (0.41) | DAOCHEK1AURKAMAP4K4ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081925-A1 | TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| US-9585884-B2 | Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2017-03-07 | — | — | US | disclosed |