Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.62 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8362658 | 1.00 | ACHE (0.62) | ACHECHRM5ADRA2CSMN1; SMN2OPRM1 | |
| SCHEMBL22875430 | 0.98 | ACHE (0.59) | ACHECHRM5ADRA2CSMN1; SMN2OPRM1 | |
| SCHEMBL17108656 | 0.94 | ACHE (0.53) | ACHECHRM5ADRA2CSMN1; SMN2OPRM1 | |
| SCHEMBL680627 | 0.90 | ACHE (0.47) | ACHECHRM5ADRA2CSMN1; SMN2OPRM1 | |
| SCHEMBL24315878 | 0.88 | ACHE (0.50) | ACHECHRM5ADRA2CSMN1; SMN2OPRM1 | |
| SCHEMBL27425161 | 0.88 | ACHE (0.45) | ACHECHRM5ADRA2COPRM1OPRL1 | |
| SCHEMBL21450690 | 0.84 | CHRM5 (0.59) | ACHECHRM5ADRA2CSMN1; SMN2OPRM1 | |
| SCHEMBL21946386 | 0.82 | NCF1 (0.42) | ACHECHRM5ADRA2C | |
| SCHEMBL20756942 | 0.82 | ACHE (0.46) | ACHECHRM5ADRA2CSMN1; SMN2OPRM1 | |
| SCHEMBL23484704 | 0.82 | ACHE (0.55) | ACHECHRM5ADRA2COPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081925-A1 | TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| US-9585884-B2 | Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2017-03-07 | — | — | US | disclosed |