Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 4/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13656199 | 0.82 | AR (0.42) | ARALDH1A1GAAMAPTSLC6A2 | |
| SCHEMBL13683731 | 0.80 | AR (0.41) | ARGAASLC6A2SLC6A4HTR2C | |
| SCHEMBL13920391 | 0.80 | AR (0.43) | ARALDH1A1HSD17B10 | |
| SCHEMBL18886131 | 0.77 | AR (0.40) | ARHTR2C | |
| SCHEMBL13059131 | 0.77 | AR (0.40) | ARHTR2C | |
| SCHEMBL24090522 | 0.77 | AR (0.40) | ARHTR2C | |
| SCHEMBL15132859 | 0.76 | ALDH1A1 (0.42) | ALDH1A1GAAMAPTHSD17B10SLC6A2 | |
| SCHEMBL8402252 | 0.75 | MMP12 (0.41) | ALDH1A1SRD5A1 | |
| SCHEMBL27010602 | 0.73 | AR (0.38) | ARALDH1A1MAPTCHRNB2CHRNA4 | |
| SCHEMBL14767424 | 0.72 | ALDH1A1 (0.39) | ALDH1A1GAAMAPTHSD17B10SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081925-A1 | TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| US-9585884-B2 | Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2017-03-07 | — | — | US | disclosed |