Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | UBE2M | P61081 | 2/20 | 0.32 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 3/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24317707 | 0.87 | MEN1 (0.37) | MEN1RAB9AKMT2AUBE2MDCUN1D1 | |
| SCHEMBL24317710 | 0.79 | DRD2 (0.37) | MEN1RAB9AKMT2AUBE2MDCUN1D1 | |
| SCHEMBL24316251 | 0.76 | DRD2 (0.36) | DRD2DRD3 | |
| SCHEMBL26617896 | 0.75 | OPRM1 (0.40) | MEN1RAB9AKMT2ADRD2DRD3 | |
| SCHEMBL24316257 | 0.75 | MEN1 (0.36) | MEN1RAB9AKMT2ADRD2DRD3 | |
| SCHEMBL12885058 | 0.73 | DRD2 (0.38) | MEN1RAB9AKMT2ADRD2DRD3 | |
| SCHEMBL10198692 | 0.72 | KDM1A (0.43) | MEN1RAB9AKMT2ADRD2DRD3 | |
| SCHEMBL12155274 | 0.72 | KDM1A (0.43) | MEN1RAB9AKMT2ADRD2DRD3 | |
| SCHEMBL13462578 | 0.72 | KDM1A (0.43) | MEN1RAB9AKMT2ADRD2DRD3 | |
| SCHEMBL12841915 | 0.71 | MEN1 (0.41) | MEN1RAB9AKMT2ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081925-A1 | TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| US-9585884-B2 | Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2017-03-07 | — | — | US | disclosed |