Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 9/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2490715 | 0.75 | DAO (0.40) | DAOALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL784395 | 0.75 | MAPK1 (0.43) | METSMN1; SMN2ALDH1A1HPGDPOLB | |
| SCHEMBL13531666 | 0.73 | SMN1; SMN2 (0.56) | METSMN1; SMN2KMT2AKDM4EHPGD | |
| SCHEMBL12747301 | 0.73 | CYP1A2 (0.41) | METGAASMN1; SMN2ALDH1A1CYP2C19 | |
| SCHEMBL12747303 | 0.73 | MET (0.38) | METGAADAOSMN1; SMN2ALDH1A1 | |
| SCHEMBL24450047 | 0.73 | DAO (0.39) | METGAADAOSMN1; SMN2ALDH1A1 | |
| SCHEMBL13130087 | 0.73 | MET (0.38) | METGAADAOSMN1; SMN2ALDH1A1 | |
| SCHEMBL4483835 | 0.73 | GAA (0.57) | METGAASMN1; SMN2ALDH1A1CYP2C19 | |
| SCHEMBL12747287 | 0.73 | MET (0.42) | METGAASMN1; SMN2ALDH1A1CYP2C19 | |
| SCHEMBL10137841 | 0.72 | SMN1; SMN2 (0.41) | METGAADAOSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081925-A1 | TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| US-9585884-B2 | Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2017-03-07 | — | — | US | disclosed |