SCHEMBL2490715

SCHEMBL2490715

CNc1cn(C)c(=O)[nH]c1=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DAO P14920 3/20 0.40
▸ CRBN Q96SW2 2/20 0.38
▸ CYP3A4 P08684 2/20 0.34
▸ PMP22 Q01453 2/20 0.34
▸ MAPK1 P28482 1/20 0.34
▸ KMT2A Q03164 3/20 0.32
▸ MEN1 O00255 2/20 0.32
▸ ALDH1A1 P00352 2/20 0.32
▸ KDM4E B2RXH2 1/20 0.32
▸ HPGD P15428 1/20 0.32
▸ MAPT P10636 2/20 0.32
▸ USP2 O75604 1/20 0.32
▸ KEAP1 Q14145 1/20 0.32
▸ NFE2L2 Q16236 1/20 0.32
▸ CYP2C9 P11712 1/20 0.32
▸ GDA Q9Y2T3 1/20 0.32
▸ KAT2B Q92831 1/20 0.32
▸ BRD9 Q9H8M2 1/20 0.32
▸ TDP1 Q9NUW8 1/20 0.31
▸ LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27905995 0.80 MEN1 (0.33) DAOKMT2AMEN1ALDH1A1HPGD
SCHEMBL28074920 0.79 DAO (0.36) DAOCRBNCYP3A4PMP22MAPK1
SCHEMBL19036625 0.77 DAO (0.35) DAOCRBNCYP3A4PMP22MAPK1
SCHEMBL24316295 0.75 MET (0.40) DAOKMT2AMEN1ALDH1A1KDM4E
SCHEMBL643987 0.73 PARP1 (0.39) DAOCYP3A4PMP22MAPK1KMT2A
SCHEMBL19036768 0.72 KMT2A (0.38) DAOCYP3A4PMP22MAPK1KMT2A
SCHEMBL16248 0.71 MAPK1 (0.47) DAOCRBNMAPK1ALDH1A1HPGD
SCHEMBL2986044 0.70 DAO (0.46) DAOCRBNCYP3A4PMP22MAPK1
SCHEMBL35345 0.70 TDP1 (0.57) DAOCRBNKMT2AMEN1ALDH1A1
SCHEMBL4379053 0.70 DAO (0.43) DAOCRBNCYP3A4PMP22MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024231230-A2 CIRCULAR NUCLEIC ACIDS AND USES THEREOF FOR SHAPING THE CELLULAR PROTEOME JUSTUS-LIEBIG-UNIVERSITÄT GIESSEN KÖRPERSCHAFT DES ÖFFENTLICHEN RECHTS (DE) 2024-11-14 — — WO disclosed
EP-4458968-A1 CIRCULAR NUCLEIC ACIDS AND USES THEREOF FOR SHAPING THE CELLULAR PROTEOME Justus-Liebig-Universität Gießen (DE) 2024-11-06 — — EP disclosed
US-20230339902-A1 TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 C4 THERAPEUTICS, INC. (US) 2023-10-26 — — US disclosed
WO-2023130021-A1 CHEMICALLY MODIFIED OLIGONUCLEOTIDES WITH IMPROVED DELIVERY PROPERTIES PHIO PHARMACEUTICALS CORP. (US) 2023-07-06 — — WO disclosed
WO-2023015264-A1 IMMUNOTHERAPY OF CANCER UTILIZING NATURAL KILLER CELLS TREATED WITH CHEMICALLY MODIFIED OLIGONUCLEOTIDES PHIO PHARMACEUTICALS CORP. (US) 2023-02-09 — — WO disclosed
WO-2023280156-A1 MODIFIED NUCLEOSIDE OR NUCLEOTIDE 深圳华大生命科学研究院 2023-01-12 — — WO disclosed
EP-4055167-A2 CHEMICALLY MODIFIED OLIGONUCLEOTIDES TARGETING BROMODOMAIN CONTAINING PROTEIN 4 (BRD4) FOR IMMUNOTHERAPY Phio Pharmaceuticals Corp. (US) 2022-09-14 — — EP disclosed
EP-4008785-A1 CIRCULAR NUCLEIC ACIDS AND USES THEREOF FOR INTERFERING WITH GENOME EXPRESSION AND PROLIFERATION OF CORONAVIRUSES Justus-Liebig-Universität Gießen (DE) 2022-06-08 — — EP disclosed
EP-3209335-A1 AGENTS FOR USE IN THE DETECTION OF NUCLEASE ACTIVITY Hernández Hincapié, Frank J. (ES) 2017-08-30 — — EP disclosed
EP-3105330-A1 MiR-21-3p INHIBITORS IN SKIN DISORDERS Université de Lausanne (CH) 2016-12-21 — — EP disclosed
EP-2057273-A2 USE OF SUBTILISIN (RNR9) POLYNUCLEOTIDES FOR ACHIEVING A PATHOGEN RESISTANCE IN PLANTS BASF Plant Science GmbH (DE) 2009-05-13 — — EP disclosed
EP-1979484-A1 USE OF STOMATIN (STM1) POLYNUCLEOTIDES FOR ACHIEVING A PATHOGEN RESISTANCE IN PLANTS BASF Plant Science GmbH (DE) 2008-10-15 — — EP disclosed
EP-1948806-A2 USE OF ARMADILLO REPEAT (ARM1) POLYNUCLEOTIDES FOR OBTAINING PATHOGEN RESISTANCE IN PLANTS BASF Plant Science GmbH (DE) 2008-07-30 — — EP disclosed
WO-2008087141-A2 USE OF SUBTILISIN (RNR9) POLYNUCLEOTIDES FOR ACHIEVING A PATHOGEN RESISTANCE IN PLANTS BASF PLANT SCIENCE GMBH (DE) 2008-07-24 — — WO disclosed
US-20080120740-A1 Novel Nucleic Acid Sequences and Their Use in Methods for Achieving a Pathogenic Resistance in Plants BASF PLANT SCIENCE GMBH (DE) 2008-05-22 — — US disclosed
WO-2007080143-A1 USE OF STOMATIN (STM1) POLYNUCLEOTIDES FOR ACHIEVING A PATHOGEN RESISTANCE IN PLANTS BASF PLANT SCIENCE GMBH (DE) 2007-07-19 — — WO disclosed
WO-2007054441-A2 USE OF ARMADILLO REPEAT (ARM1) POLYNUCLEOTIDES FOR OBTAINING PATHOGEN RESISTANCE IN PLANTS BASF PLANT SCIENCE GMBH (DE) 2007-05-18 — — WO disclosed
EP-1747275-A2 NOVEL NUCLEIC ACID SEQUENCES AND THEIR USE IN METHODS FOR ACHIEVING A PATHOGENIC RESISTANCE IN PLANTS BASF Plant Science GmbH (DE) 2007-01-31 — — EP disclosed
WO-2005111215-A2 NOVEL NUCLEIC ACID SEQUENCES AND THEIR USE IN METHODS FOR ACHIEVING A PATHOGENIC RESISTANCE IN PLANTS BASF PLANT SCIENCE GMBH (DE) 2005-11-24 — — WO disclosed
US-20030082678-A1 Methods and compositions for regulating body weight in bovine species ELI LILLY AND COMPANY 2003-05-01 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230339902-A1 TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 IKZF1, IKZF3, IKZF2 DAO 4160/4885CRBN 50/4885CYP3A4 2637/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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