Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 5/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | CALM1 | P0DP23 | 2/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | AGXT | P21549 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21327653 | 0.85 | CSF1R (0.54) | APPCNR1CNR2NPC1POLB | |
| SCHEMBL24316413 | 0.84 | APP (0.45) | APPCNR1CNR2NPC1POLB | |
| SCHEMBL19461724 | 0.81 | CSF1R (0.46) | APPCNR1CNR2NPC1POLB | |
| SCHEMBL24316415 | 0.80 | CNR1 (0.47) | APPCNR1CNR2NPC1POLB | |
| SCHEMBL19555332 | 0.76 | CYP3A4 (0.37) | POLB | |
| SCHEMBL24316420 | 0.76 | MAOB (0.45) | NPC1POLBRAB9ASMN1; SMN2MAOB | |
| SCHEMBL24317098 | 0.76 | APP (0.51) | APPNPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL31402943 | 0.75 | APP (0.51) | APPNPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL19527337 | 0.75 | NPC1 (0.57) | TLR8APPCNR1CNR2CYP17A1 | |
| SCHEMBL26326725 | 0.75 | CSF1R (0.59) | APPCNR1CNR2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022057895-A1 | HETEROAROMATIC COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2022-03-24 | — | — | WO | disclosed |
| US-9585884-B2 | Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2017-03-07 | — | — | US | disclosed |