Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21327653 | 0.88 | CSF1R (0.54) | MAOBNPC1RAB9ACSF1RSMN1; SMN2 | |
| SCHEMBL24316985 | 0.87 | MRGPRX4 (0.49) | MAOBNPC1RAB9ACSF1RSMN1; SMN2 | |
| SCHEMBL24316419 | 0.86 | PDGFRB (0.49) | MAOBNPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL24316988 | 0.83 | CHRM4 (0.41) | NPC1RAB9ACSF1RMAPTALDH1A1 | |
| SCHEMBL24316418 | 0.82 | CSF1R (0.41) | CSF1R | |
| SCHEMBL24316987 | 0.79 | DHODH (0.38) | NPC1RAB9ACSF1RLMNASCN9A | |
| SCHEMBL19461724 | 0.78 | CSF1R (0.46) | MAOBNPC1RAB9ACSF1RSMN1; SMN2 | |
| SCHEMBL24316986 | 0.77 | KDM4E (0.50) | MAOBHPGDMAPTLMNAALOX12 | |
| SCHEMBL324131 | 0.76 | CYP3A4 (0.46) | MAOBMAPTALDH1A1SMPD3 | |
| SCHEMBL24316414 | 0.76 | TLR8 (0.48) | MAOBNPC1RAB9ACSF1RSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022057895-A1 | HETEROAROMATIC COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2022-03-24 | — | — | WO | disclosed |
| US-9585884-B2 | Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2017-03-07 | — | — | US | disclosed |