Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | GALR3 | O60755 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27010431 | 0.88 | PTGDR2 (0.43) | PTGDR2ALDH1A1TSHRNPC1SMN1; SMN2 | |
| SCHEMBL26620496 | 0.87 | PTGDR2 (0.46) | PTGDR2ALDH1A1TSHRNPC1SMN1; SMN2 | |
| SCHEMBL27010306 | 0.86 | PTGDR2 (0.46) | PTGDR2ALDH1A1TSHRNPC1SMN1; SMN2 | |
| SCHEMBL27010436 | 0.86 | PTGDR2 (0.44) | PTGDR2ALDH1A1TSHRNPC1SMN1; SMN2 | |
| SCHEMBL24316060 | 0.86 | PTGDR2 (0.48) | PTGDR2ALDH1A1TSHRNPC1SMN1; SMN2 | |
| SCHEMBL26620168 | 0.84 | PTGDR2 (0.47) | PTGDR2ALDH1A1TSHRNPC1SMN1; SMN2 | |
| SCHEMBL26636472 | 0.83 | PTGDR2 (0.46) | PTGDR2ALDH1A1TSHRNPC1SMN1; SMN2 | |
| SCHEMBL27010304 | 0.83 | PTGDR2 (0.45) | PTGDR2ALDH1A1TSHRNPC1SMN1; SMN2 | |
| SCHEMBL26620187 | 0.82 | NPC1 (0.46) | PTGDR2ALDH1A1TSHRNPC1SMN1; SMN2 | |
| SCHEMBL24315678 | 0.81 | PTGDR2 (0.43) | PTGDR2ALDH1A1TSHRNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240018118-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | C 4 Therapeutics, Inc. (US) | 2024-01-18 | — | — | US | disclosed |
| WO-2022081927-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240018118-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | NFATC1, CTSS, MMP12 | PTGDR2 2093/4885ALDH1A1 2267/4885TSHR 2445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.