Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.46 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.44 |
| ▸ | TYMS | P04818 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14867283 | 0.93 | KDM4E (0.50) | PARP1KDM4EALDH1A1NPC1HPGD | |
| SCHEMBL12323930 | 0.92 | SERPINE1 (0.51) | PARP1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL12323935 | 0.87 | PARP1 (0.57) | PARP1KDM4EALDH1A1NPC1HPGD | |
| SCHEMBL12324316 | 0.84 | MAPK13 (0.50) | PARP1KDM4EALDH1A1NPC1HPGD | |
| SCHEMBL12324329 | 0.84 | KDM4E (0.48) | PARP1KDM4EALDH1A1NPC1HPGD | |
| SCHEMBL12323816 | 0.84 | SERPINE1 (0.62) | PARP1KDM4EALDH1A1NPC1HPGD | |
| SCHEMBL14871604 | 0.84 | KDM4E (0.49) | PARP1KDM4EALDH1A1NPC1HPGD | |
| SCHEMBL12323809 | 0.82 | KDM4E (0.47) | PARP1KDM4EALDH1A1NPC1HPGD | |
| SCHEMBL12324324 | 0.82 | MAOB (0.51) | PARP1KDM4EALDH1A1NPC1HPGD | |
| SCHEMBL12324330 | 0.80 | KDM4E (0.48) | PARP1KDM4EALDH1A1NPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2542239-B1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | Université Joseph Fourier (FR) | 2015-11-11 | — | — | EP | disclosed |
| EP-2542239-B1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | Université Joseph Fourier (FR) | 2015-11-11 | — | — | EP | disclosed |
| US-8883763-B2 | Use of isoquinolones for preparing drugs, novel isoquinolones and method for synthesising same | UNIVERSITE JOSEPH FOURIER (FR) | 2014-11-11 | — | — | US | disclosed |
| US-8883763-B2 | Use of isoquinolones for preparing drugs, novel isoquinolones and method for synthesising same | UNIVERSITE JOSEPH FOURIER (FR) | 2014-11-11 | — | — | US | disclosed |
| US-8883763-B2 | Use of isoquinolones for preparing drugs, novel isoquinolones and method for synthesising same | UNIVERSITE JOSEPH FOURIER (FR) | 2014-11-11 | — | — | US | disclosed |
| US-20130096083-A1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | UNIVERSITE JOSEPH FOURIER (FR) | 2013-04-18 | — | — | US | disclosed |
| US-20130096083-A1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | UNIVERSITE JOSEPH FOURIER (FR) | 2013-04-18 | — | — | US | disclosed |
| US-20130096083-A1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | UNIVERSITE JOSEPH FOURIER (FR) | 2013-04-18 | — | — | US | disclosed |
| EP-2542239-A1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | Université Joseph Fourier (FR) | 2013-01-09 | — | — | EP | disclosed |
| WO-2011107709-A1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | UNIVERSITE JOSEPH FOURIER (FR) | 2011-09-09 | — | — | WO | disclosed |
| WO-2011107709-A1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | UNIVERSITE JOSEPH FOURIER (FR) | 2011-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096083-A1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | GNAQ, HCCS, SDHA | PARP1 551/4885KDM4E 1796/4885ALDH1A1 2507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.