Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRB | P23467 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770076 | 0.86 | PTPRB (0.50) | PTPRBKMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL24318145 | 0.86 | PTPRB (0.53) | PTPRBKMT2AMEN1RAB9ACYP3A4 | |
| SCHEMBL19775198 | 0.83 | PTPRB (0.77) | PTPRB | |
| SCHEMBL24319135 | 0.82 | PTPRB (0.56) | PTPRBSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL24767057 | 0.81 | PTPRB (0.42) | PTPRBRAB9APOLBMAPT | |
| SCHEMBL24767062 | 0.80 | PTPRB (0.38) | PTPRBCYP2D6CYP2C19 | |
| SCHEMBL24767156 | 0.79 | PTPRB (0.51) | PTPRBSMN1; SMN2KMT2APOLBCYP3A4 | |
| SCHEMBL24318149 | 0.78 | PTPRB (0.45) | PTPRBLMNAKMT2AMEN1KDM4E | |
| SCHEMBL23769990 | 0.77 | PTPRB (0.56) | PTPRB | |
| SCHEMBL24767305 | 0.77 | PTPRB (0.49) | PTPRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4101297-A1 | COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES | Aerpio Pharmaceuticals, Inc. (US) | 2022-12-14 | — | — | EP | disclosed |
| EP-3977994-A1 | ACTIVATORS OF TIE-2 FOR USE IN TREATING INTRAOCULAR PRESSURE | Aerpio Pharmaceuticals, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |