Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRB | P23467 | 11/20 | 0.45 |
| ▸ | F11 | P03951 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23769990 | 0.91 | PTPRB (0.56) | PTPRBF11CDK8 | |
| SCHEMBL24767156 | 0.90 | PTPRB (0.51) | PTPRBF11KMT2ACYP1A2CYP3A4 | |
| SCHEMBL24319135 | 0.89 | PTPRB (0.56) | PTPRBF11MEN1ALDH1A1KMT2A | |
| SCHEMBL23770076 | 0.83 | PTPRB (0.50) | PTPRBMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL24767308 | 0.83 | ALDH1A1 (0.36) | PTPRBALDH1A1 | |
| SCHEMBL24318145 | 0.79 | PTPRB (0.53) | PTPRBMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL24319129 | 0.78 | PTPRB (0.55) | PTPRBMEN1ALDH1A1KMT2ACYP3A4 | |
| SCHEMBL24767257 | 0.77 | PTPRB (0.69) | PTPRB | |
| SCHEMBL23770301 | 0.77 | PTPRB (0.73) | PTPRB | |
| SCHEMBL23770161 | 0.77 | PTPRB (0.53) | PTPRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3977994-A1 | ACTIVATORS OF TIE-2 FOR USE IN TREATING INTRAOCULAR PRESSURE | Aerpio Pharmaceuticals, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |