Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 2/20 | 0.31 |
| ▸ | NOS1 | P29475 | 2/20 | 0.31 |
| ▸ | NOS2 | P35228 | 2/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12717990 | 1.00 | NCF1 (0.41) | NCF1KDM4EALDH1A1NOS3NOS1 | |
| SCHEMBL26762607 | 0.85 | NCF1 (0.41) | NCF1KDM4EALDH1A1NOS3NOS1 | |
| SCHEMBL10202213 | 0.84 | NCF1 (0.46) | NCF1KDM4EALDH1A1NOS3NOS1 | |
| SCHEMBL21101619 | 0.84 | NCF1 (0.46) | NCF1KDM4EALDH1A1NOS3NOS1 | |
| SCHEMBL12714595 | 0.84 | NCF1 (0.44) | NCF1KDM4EALDH1A1NOS3NOS1 | |
| SCHEMBL23171672 | 0.84 | NCF1 (0.39) | NCF1KDM4EALDH1A1NOS3NOS1 | |
| SCHEMBL23171913 | 0.84 | NCF1 (0.39) | NCF1KDM4EALDH1A1NOS3NOS1 | |
| SCHEMBL23128851 | 0.82 | NCF1 (0.45) | NCF1KDM4EALDH1A1NOS3NOS1 | |
| SCHEMBL26347919 | 0.81 | KDM4E (0.38) | NCF1KDM4EALDH1A1NOS3NOS1 | |
| SCHEMBL24319184 | 0.81 | NCF1 (0.37) | NCF1KDM4EALDH1A1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |