Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 1/20 | 0.50 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.50 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.50 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 7/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14520866 | 1.00 | CARM1 (0.50) | CARM1PRMT6PRMT1PRMT8SIGMAR1 | |
| SCHEMBL7278153 | 0.89 | CARM1 (0.48) | CARM1PRMT6PRMT1PRMT8SIGMAR1 | |
| SCHEMBL8085877 | 0.84 | CARM1 (0.52) | CARM1PRMT6PRMT1PRMT8SIGMAR1 | |
| SCHEMBL9319178 | 0.81 | HRH3 (0.38) | HTTHRH3KMT2ADRD2DRD3 | |
| SCHEMBL14520867 | 0.81 | SIGMAR1 (0.49) | CARM1PRMT6PRMT1PRMT8SIGMAR1 | |
| SCHEMBL12424417 | 0.80 | MEN1 (0.50) | CARM1PRMT6PRMT1PRMT8SIGMAR1 | |
| SCHEMBL22544217 | 0.80 | MEN1 (0.50) | CARM1PRMT6PRMT1PRMT8SIGMAR1 | |
| SCHEMBL20234635 | 0.78 | CARM1 (0.65) | CARM1PRMT6PRMT1PRMT8SIGMAR1 | |
| SCHEMBL8557028 | 0.78 | CARM1 (0.55) | CARM1PRMT6PRMT1PRMT8SIGMAR1 | |
| SCHEMBL6220241 | 0.78 | NCF1 (0.52) | CARM1PRMT6PRMT1PRMT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |